Identification and Cancer Therapeutic Properties of Microfloral Anthocyanin Metabolites
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چکیده
Colon cancer is very common, but those who consume anthocyanins, common red pigments in wine, grapes and other fruits, appear to have lower rates of colon cancer. We investigated the fate of grape anthocyanins in the colon by using a pig model of the lower intestine and observed the rapid conversion to three simple phenols. These were studied, along with metabolites reported by others, for their effect on cell proliferation and apoptosis, and we observed promising results; cell proliferation was suppressed and apoptosis enhanced. Thus, these metabolites are promising anti-cancer agents and the effect of anthocyanins on colon cancer appears to be mediated by these bacterial metabolites.
منابع مشابه
Gut metabolites of anthocyanins, gallic acid, 3-O-methylgallic acid, and 2,4,6-trihydroxybenzaldehyde, inhibit cell proliferation of Caco-2 cells.
Gut microflora metabolize anthocyanins to phenolic acids and aldehydes. These metabolites may explain the relationship between anthocyanin consumption and reduced incidence of colon cancer. Here, all six major metabolites, along with a Cabernet Sauvignon anthocyanin extract, were incubated with Caco-2 cells at concentrations of 0-1000 microM over 72 h to determine effects on cell proliferation ...
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تاریخ انتشار 2011